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KMID : 0848120120370040161
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International Journal of Oral Biology
2012 Volume.37 No. 4 p.161 ~ p.166
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Expression of Deleted in Colorectal Cancer in the Rat Trigeminal Ganglia
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Kim Sun-Hun
Lee Eun-Joo
Kim Nam-Ryang
Yoo Hong-Il
Yang So-Young
Kang Jee-Hae
Kim Hyun-Jin
Kim Min-Seok
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Abstract
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The deleted in colorectal cancer (DCC) protein mediates attractant responses to netrin during axonogenesis. In the rat trigeminal ganglia (TG), axons must extend toward and grow into the trigeminal nerve to innervate target tissues such as dental pulp. Our present study aimed to investigate the exp-ression of DCC in the TG. Four developmental timepoints were assessed in the experiments: postnatal days 0, 7 and 10 and adulthood. RT-PCR and western blotting revealed that the expression of DCC mRNA and protein does not signi-ficantly change throughout development. Immunohistoche-mistry demonstrated that DCC expression in the TG was detectable in the perikarya region of the ganglion cells du-ring development. Nerve injury at 3 and 5 days after the man-dibular nerve had been cut did not induce altered expression of DCC mRNA in the TG. Moreover, DCC-positive cell bodies also showed similar immunoreactive patterns after a nerve cut injury. The results of this study suggest that DCC constituti-vely participates in an axonogenesis attractant in ways other than expression regulation.
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KEYWORD
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DCC, TG, Nerve
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